NACOGDOCHES, TEXAS. Nacogdoches, the county seat of Nacogdoches County, is on State highways 7, 21, 59 (a principal artery to Houston), and 259, fifty miles west of the Sabine River and 100 miles north of Beaumont in the central part of the county. It was named for the Nacogdoche Indians, a Caddo group. Archeological research has established that mounds found in the area date from approximately A.D. 1250, when the Indians built lodges along Lanana and Bonita creeks, which converge just south of Nacogdoches and continue as a single stream to the Angelina River.